(2R)-Oxirane-2-Carboxylic Acid Methyl Ester

(2R)-Oxirane-2-Carboxylic Acid Methyl Ester - Names and Identifiers

Name	(R)-Methyglycidate
Synonyms	(r)-methyglycidate (R)-Methyclycidate (R)-Methyglycidate R-Methyl Oxiranecarboxylate R-METHYL OXIRANECARBOXYLATE Methyl (R)-Oxiranecarboxylate methyl (r)-oxiranecarboxylate (R)-Glycidic Acid Methyl Ester (R)-Methyl oxirane-2-carboxylate Methyl (2R)-Oxirane-2-Carboxylate methyl (2r)-oxirane-2-carboxylate (2R)-Oxirane-2-Carboxylic Acid Methyl Ester
CAS	111058-32-3
EINECS	601-036-5
InChI	InChI=1/C4H6O3/c1-6-4(5)3-2-7-3/h3H,2H2,1H3/t3-/m1/s1
InChIKey	YKNYRRVISWJDSR-GSVOUGTGSA-N

(2R)-Oxirane-2-Carboxylic Acid Methyl Ester - Physico-chemical Properties

Molecular Formula	C4H6O3
Molar Mass	102.09
Density	1.166 g/mL at 25 °C (lit.)
Boling Point	97.4±15.0 °C(Predicted)
Specific Rotation(α)	32 º (c=1, chloroform)
Flash Point	162°F
Solubility	Acetonitrile (Slightly), Chloroform (Soluble), Ethyl Acetate (Slightly)
Vapor Presure	41.693mmHg at 25°C
Appearance	Oil
Color	Colourless
Storage Condition	2-8°C
Stability	Volatile
Refractive Index	n20/D 1.42(lit.)
Physical and Chemical Properties	WGK Germany:3

(2R)-Oxirane-2-Carboxylic Acid Methyl Ester - Risk and Safety

Hazard Symbols	Xi - Irritant
Risk Codes	36/37/38 - Irritating to eyes, respiratory system and skin.
Safety Description	S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36 - Wear suitable protective clothing.
UN IDs	NA 1993 / PGIII
WGK Germany	3

(2R)-Oxirane-2-Carboxylic Acid Methyl Ester - Introduction

Methyl (R)-glycidate, chemically known as benzyl (R)-2-methoxycarbonylpropionate, is an organic compound. The following is a description of its nature, use, preparation and safety information:

Nature:
1. Appearance:(R)-Glycidate methyl ester is a colorless liquid.
2. molecular formula: C10H12O3
3. Molecular weight: 180.2g/mol
4. Boiling point: 260-262°C
5. Melting point:-8°C
6. may have a sweet smell.
7. insoluble in water, soluble in organic solvents such as ethanol and ether.

Use:
1. Methyl (R)-glycidate can be used as a catalyst and a reaction mediator in organic synthesis.
2. It is widely used in drug synthesis, such as the synthesis of drugs without blockers, the synthesis of naphthyridine and pyridine drugs.
3. It is also used in pesticide synthesis and spice synthesis.

Preparation Method:
Methyl (R)-glycidate can be prepared by condensation of phenylacetone. For specific synthetic methods, reference can be made to the relevant literature such as the Handbook of Organic Synthetic Chemistry.

Safety Information:
1. (R)-methyl glycinate is an organic compound and should be used with protective measures, such as wearing protective gloves and masks.
2. Exposure to or inhalation of high concentrations of methyl (R)-glycidate may cause irritation and injury, and may cause irritation of the eyes and respiratory tract.
3. swallowed or ingested may cause poisoning, should be used with caution and avoid ingestion.
4. avoid contact with oxidants, strong acids, strong bases and other substances to avoid dangerous reactions.

Last Update：2024-04-09 02:00:41